Protein Optimization & Binder Discovery

From challenging proteins to effective molecules.

EvoProt combines structure-guided engineering, computational design, and ultra-high-throughput directed evolution, turning your hardest protein optimization challenges into commercially viable solutions.

EvoProt protein helix icon
01 / Services

Scientific services built around your target.

1

Protein and Enzyme Optimization

Push beyond natural limits. Simultaneous multi-property optimization across thermostability, solubility, catalytic efficiency, and target specificity. Our iterative engineering cycles deliver molecules that perform under real-world conditions.

2

De Novo Binder and Scaffold Discovery

High-affinity binder discovery with an emphasis on kinetic performance, stability, manufacturability, and non-antibody scaffolds.

3

Immunogenicity Engineering

Reduce immunogenic liability without compromising potency through epitope removal, humanization, and targeted deimmunization strategies.

4

Production and Applied Protein Engineering

Recombinant production, expression optimization, targeted modification, and mutation library creation for clinical, industrial, and research workflows.

02 / Process

End-to-end support from early design through applied production.

1

Characterise

Deep structural and functional analysis to establish precise engineering coordinates and identify key liabilities.

2

Design

Rational variant design, computational landscape mapping, identification of key domains.

3

Evolve

Ultra-high-throughput directed evolution across rapid iterative selection cycles with simultaneous multi-property pressure.

4

Select

Multi-property simultaneous screening and quantitative hit characterisation.

5

Deliver

Validated sequences, expression constructs, and a full technical documentation package.

03 / Blog

Peer-reviewed science at the foundation.

All posts
Nature Communications 2025

Interprotomer Antibody Deglycosylation

Read paper
Nature Communications 2024

Distinct Gut ENGases on Shared N-Glycans

Read paper
Cell 2024

Potent Efficacy of an IgG-Specific Endoglycosidase Against IgG-Mediated Pathologies

Read paper
FEBS Journal 2023

Integrated Display Workflows for IL-9Rα Engineering

Read paper